Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 14/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087862 | 0.90 | SERPINE1 (0.58) | SERPINE1ENPP2 | |
| SCHEMBL7163081 | 0.84 | SERPINE1 (0.54) | SERPINE1ENPP2 | |
| SCHEMBL7084122 | 0.83 | SERPINE1 (0.53) | SERPINE1ENPP2POLB | |
| SCHEMBL7087880 | 0.78 | SERPINE1 (0.57) | SERPINE1ENPP2 | |
| SCHEMBL7090999 | 0.77 | SERPINE1 (0.79) | SERPINE1POLBLMNAMAPTHTT | |
| SCHEMBL7088384 | 0.77 | SERPINE1 (0.56) | SERPINE1ENPP2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL30883140 | 0.74 | SERPINE1 (0.61) | SERPINE1ENPP2POLBLMNAMAPT | |
| SCHEMBL7087875 | 0.73 | SERPINE1 (0.77) | SERPINE1ENPP2POLB | |
| SCHEMBL7088465 | 0.72 | SERPINE1 (0.80) | SERPINE1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL7089626 | 0.72 | SERPINE1 (0.51) | SERPINE1ENPP2PTGDR2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080060-A1 | SUBSTITUTED PIPERAZINE ANTITHROMBOTIC PAI-1 INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | WO | disclosed |