Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020205 | 0.80 | SCN4A (0.55) | DYRK1AGSK3AGSK3BKMT2AMAPK1 | |
| SCHEMBL7090587 | 0.80 | MAP2K4 (0.40) | DYRK1AGSK3BTTKMAPK1MKNK1 | |
| SCHEMBL8251865 | 0.77 | MAP2K4 (0.68) | PRKAG1PRKAA1PRKAB1DYRK1AGSK3A | |
| SCHEMBL5382842 | 0.76 | PRKAG1 (0.48) | PRKAG1PRKAA1PRKAB1LRRK2DYRK1A | |
| SCHEMBL4009086 | 0.76 | AXL (0.55) | PRKAG1PRKAA1PRKAB1LRRK2DYRK1A | |
| Hydrochloric Acid SCHEMBL5390659 | 0.75 | AXL (0.53) | PRKAG1PRKAA1PRKAB1LRRK2DYRK1A | |
| SCHEMBL8268311 | 0.75 | PRKAG1 (0.49) | PRKAG1PRKAA1PRKAB1LRRK2DYRK1A | |
| SCHEMBL5386179 | 0.74 | GSK3B (0.52) | PRKAG1PRKAA1PRKAB1LRRK2DYRK1A | |
| SCHEMBL4736181 | 0.73 | NTRK1 (0.56) | LRRK2DYRK1AGSK3AGSK3BTTK | |
| SCHEMBL5385898 | 0.73 | LRRK2 (0.59) | PRKAG1PRKAA1PRKAB1LRRK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |