Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893714 | 0.87 | KMT2A (0.49) | KDM4ESMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL752884 | 0.81 | KDM4E (0.65) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL11360558 | 0.81 | KDM4E (0.53) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL6045428 | 0.79 | TTR (0.52) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL29587413 | 0.79 | TTR (0.52) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL15820941 | 0.78 | TTR (0.50) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL3417705 | 0.78 | CA1 (0.61) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL15820937 | 0.78 | TTR (0.50) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL29591307 | 0.78 | CA1 (0.61) | MAOAKDM4ECYP3A4SMN1; SMN2MAPT | |
| SCHEMBL5972191 | 0.78 | MEN1 (0.49) | KDM4ECYP3A4SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353915-A2 | THERAPEUTIC CHROMAN COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002055014-A2 | THERAPEUTIC CHROMAN COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |