SCHEMBL7092270

SCHEMBL7092270

[CH2]CCc1ccc(F)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DAO P14920 3/20 0.44
HTT P42858 2/20 0.42
ALDH1A1 P00352 1/20 0.42
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39
CYP17A1 P05093 1/20 0.37
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
TAAR1 Q96RJ0 2/20 0.34
RIPK1 Q13546 1/20 0.34
KDM1A O60341 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16953418 0.86 DAO (0.42) DAOHTTALDH1A1MAOAMAOB
SCHEMBL16105820 0.85 DAO (0.55) DAOHTTALDH1A1MAOAMAOB
SCHEMBL6649880 0.85 DAO (0.41) DAOHTTALDH1A1MAOAMAOB
SCHEMBL9579438 0.83 DAO (0.40) DAOHTTALDH1A1MAOAMAOB
SCHEMBL10823078 0.80 PNMT (0.45) TAAR1
SCHEMBL8084327 0.80 KDM1A (0.35) DAOTAAR1KDM1A
SCHEMBL15517152 0.80 DAO (0.45) DAOHTTALDH1A1MAOBTAAR1
SCHEMBL126440 0.80 HTT (0.45) DAOHTTALDH1A1MAOAMAOB
SCHEMBL631580 0.78 TAAR1 (0.58) DAOALDH1A1MAOBTAAR1
SCHEMBL3246622 0.78 DAO (0.46) DAOHTTALDH1A1MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102656163-B Suppress the heterogeneous ring compound of PASK BIOENERGENIX (US) 2016-01-13 CN claimed
CN-103459382-A Heterocyclic compounds for the inhibition of pask BIOENERGENIX LLC 2013-12-18 CN claimed
US-20030232994-A1 Bicyclic thiophene derivatives and combinatorial libraries thereof LION BIOSCIENCE AG (DE) 2003-12-18 US claimed
US-11118072-B2 Water repellent film-forming composition and water repellent film SHIN-ETSU CHEMICAL CO., LTD. (JP) 2021-09-14 US disclosed
EP-3553121-B1 WATER REPELLENT FILM-FORMING COMPOSITION AND WATER REPELLENT FILM SHINETSU CHEMICAL CO (JP) 2021-06-09 EP disclosed
CN-110358445-A Water repellent film, which is formed, uses composition and water repellent film 信越化学工业株式会社 2019-10-22 CN disclosed
US-20190315972-A1 WATER REPELLENT FILM-FORMING COMPOSITION AND WATER REPELLENT FILM SHIN-ETSU CHEMICAL CO., LTD. (JP) 2019-10-17 US disclosed
EP-3553121-A1 WATER REPELLENT FILM-FORMING COMPOSITION AND WATER REPELLENT FILM Shin-Etsu Chemical Co., Ltd. (JP) 2019-10-16 EP disclosed
CN-107141313-A Transparent oxide electrode and its production method that surface modifier, surface for transparent oxide electrode are modified 信越化学工业株式会社 2017-09-08 CN disclosed
CN-102656163-B Suppress the heterogeneous ring compound of PASK BIOENERGENIX (US) 2016-01-13 CN disclosed
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed
CN-103848859-A Surface modifier for transparent oxide electrode, surface-modified transparent oxide electrode, and method for producing same SHINETSU CHEMICAL CO 2014-06-11 CN disclosed
US-20030232994-A1 Bicyclic thiophene derivatives and combinatorial libraries thereof LION BIOSCIENCE AG (DE) 2003-12-18 US disclosed
EP-0880524-B1 ADENOSIN ANTAGONISTS, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS BOEHRINGER INGELHEIM PHARMA (DE) 2000-04-19 EP disclosed
EP-0978517-A2 Triazolopurines, process for their preparation and their use as medicaments Boehringer Ingelheim Pharma KG (DE) 2000-02-09 EP disclosed
EP-0880524-A1 NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS Boehringer Ingelheim Pharma KG (DE) 1998-12-02 EP disclosed
WO-1998003511-A1 NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS BOEHRINGER INGELHEIM PHARMA KG (DE) 1998-01-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030232994-A1 Bicyclic thiophene derivatives and combinatorial libraries thereof CXCR2, BICRA, CXCR1 DAO 3672/4885HTT 1512/4885ALDH1A1 928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.