Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096653 | 0.87 | EPHX2 (0.59) | EPHX2ALDH1A1TSHRCHRNA7SMN1; SMN2 | |
| SCHEMBL13873652 | 0.87 | EPHX2 (0.58) | EPHX2ALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL4105262 | 0.87 | CHRNA7 (0.66) | EPHX2ALDH1A1TSHRCHRNA7SMN1; SMN2 | |
| SCHEMBL13873498 | 0.87 | EPHX2 (0.64) | EPHX2ALDH1A1TSHRCHRNA7SMN1; SMN2 | |
| SCHEMBL13873823 | 0.85 | EPHX2 (0.56) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4101221 | 0.85 | EPHX2 (0.61) | EPHX2ALDH1A1TSHRCHRNA7SMN1; SMN2 | |
| SCHEMBL12466289 | 0.85 | EPHX2 (0.61) | EPHX2ALDH1A1TSHRCHRNA7SMN1; SMN2 | |
| SCHEMBL7699864 | 0.84 | EPHX2 (0.51) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13890321 | 0.83 | EPHX2 (0.59) | EPHX2ALDH1A1TSHRCHRNA7SMN1; SMN2 | |
| SCHEMBL7091498 | 0.82 | ADRB1 (0.62) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605618-B2 | Antidiabetic agents; hypoglycemic agents; anticholesterol agents; side effect reduction | WYETH | 2003-08-12 | — | — | US | disclosed |
| US-20030018045-A1 | Heterocyclic beta-3 adrenergic receptor agonists | WYETH (US) | 2003-01-23 | — | — | US | disclosed |
| US-6451814-B1 | SUBSTITUTED 4-((4-AMINO-5-HYDROXYPHENYL)-OXY-)PIPERIDINE ANALOGS; METABOLIC DISORDERS; ANTIDIABETIC AGENTS; ATHERO-SCLEROSIS, GASTROINTESTINAL DISORDERS, GLAUCOMA, NEUROGENETIC INFLAMMATION, OCULAR HYPERTENSION AND FREQUENT URINATION | WYETH | 2002-09-17 | — | — | US | disclosed |
| US-20020028832-A1 | Heterocyclic beta-3 adrenergic receptor agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018045-A1 | Heterocyclic beta-3 adrenergic receptor agonists | ADRB2, ADRB1, ADRB3 | EPHX2 1109/4885ALDH1A1 725/4885TSHR 603/4885 |
| US-20020028832-A1 | Heterocyclic beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | EPHX2 1674/4885ALDH1A1 524/4885TSHR 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.