Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ING2 | Q9H160 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 3/20 | 0.40 |
| ▸ | NSD2 | O96028 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 3/20 | 0.39 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3495112 | 0.95 | ING2 (0.54) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL7590808 | 0.93 | ING2 (0.48) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL3309996 | 0.86 | ING2 (0.47) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL28747107 | 0.86 | ING2 (0.47) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL772207 | 0.86 | ING2 (0.47) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL22221 | 0.86 | ING2 (0.47) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL17627830 | 0.86 | ING2 (0.47) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL7088257 | 0.85 | ING2 (0.45) | ING2LCKFYNALDH1A1HSD17B10 | |
| SCHEMBL11413481 | 0.85 | ING2 (0.45) | ING2LCKFYNALDH1A1HSD17B10 | |
| Water SCHEMBL3205307 | 0.85 | ING2 (0.45) | ING2LCKFYNALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649753-B2 | S-adenosyl-L-methionine derivative for use in the treatment of brain disorders | ORCHID CHEMICALS & PHARMACEUTICALS LTD. (IN) | 2003-11-18 | — | — | US | disclosed |
| US-20030032796-A1 | New stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED, INDIA | 2003-02-13 | — | — | US | disclosed |