Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086541 | 0.91 | MAPT (0.43) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7093569 | 0.82 | MAPT (0.49) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7090098 | 0.79 | MAPT (0.41) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7089217 | 0.77 | MAPT (0.47) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6512798 | 0.76 | HDAC3 (0.46) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6512792 | 0.76 | HDAC3 (0.46) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6515164 | 0.76 | HDAC3 (0.46) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7084609 | 0.76 | MAPT (0.61) | MAPTSMN1; SMN2HTTLMNAKDM4E | |
| SCHEMBL6514290 | 0.75 | MAPT (0.45) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6512816 | 0.75 | THRB (0.50) | MAPTHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |