Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 9/20 | 0.58 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377562 | 0.81 | NTRK1 (0.50) | FFAR1PPARGMAPK1TBXAS1 | |
| SCHEMBL2864256 | 0.79 | MAP2K4 (0.52) | PIM1MAPK3MAPK1 | |
| SCHEMBL12907094 | 0.75 | TBXAS1 (0.47) | FFAR1PPARGTBXAS1 | |
| SCHEMBL4325524 | 0.72 | PIM1 (0.53) | PIM1 | |
| SCHEMBL22445936 | 0.72 | PIM1 (0.53) | PIM1 | |
| SCHEMBL2857478 | 0.72 | MAP2K4 (0.52) | PIM1MAPK3MAPK1 | |
| SCHEMBL6502471 | 0.72 | MAPK1 (0.55) | MAPK3MAPK1 | |
| SCHEMBL13207885 | 0.72 | PIM1 (0.51) | PIM1 | |
| SCHEMBL28177130 | 0.71 | IDO1 (0.58) | PIM1 | |
| SCHEMBL8634851 | 0.70 | FFAR1 (0.66) | FFAR1PPARGFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |