Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11661462 | 0.98 | MAPT (0.57) | MAPTADRA1AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23440267 | 0.83 | KDM4E (0.51) | MAPTALDH1A1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL3477694 | 0.83 | BRD4 (0.52) | ALDH1A1KDM4EEDNRATSHRKMT2A | |
| SCHEMBL11651032 | 0.81 | POLB (0.55) | MAPTADRA1AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11661464 | 0.81 | POLB (0.55) | MAPTADRA1AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7243110 | 0.81 | MAPK1 (0.61) | MAPTEDNRATSHRKMT2AMEN1 | |
| SCHEMBL1390671 | 0.80 | EDNRB (0.53) | MAPTALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL8065463 | 0.79 | ALDH1A1 (0.48) | MAPTADRA1AALDH1A1KDM4EEDNRA | |
| SCHEMBL5564296 | 0.78 | CA12 (0.54) | MAPTALDH1A1SMN1; SMN2LMNACYP2C9 | |
| SCHEMBL28575287 | 0.78 | SCN9A (0.41) | ALDH1A1KDM4EKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638921-B1 | Pharmaceutically acceptable derivatives thereof Cx, R1 and R2 being as defined in the disclosure may be used to inhibit the activity of HIV integrase. | PHARMACOR INC. (CA) | 2003-10-28 | — | — | US | disclosed |
| WO-2003082881-A2 | PYRIDOXAL-5-PHOSPHATE DERIVATIVES AS HIV INTEGRASE INHIBITORS | PROCYON BIOPHARMA INC. (CA) | 2003-10-09 | — | — | WO | disclosed |
| US-4172079-A | Preparation of 4-nitroisoxazoles | TEXACO INC. (US) | 1979-10-23 | — | — | US | disclosed |
| US-4102806-A | DISPERSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1978-07-25 | — | — | US | disclosed |