Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 11/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093795 | 0.88 | GABRA1 (0.39) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL342539 | 0.83 | GABRG2 (0.42) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7093278 | 0.83 | GABRA1 (0.33) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341480 | 0.82 | GABRG2 (0.54) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6772522 | 0.80 | GABRG2 (0.38) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6779561 | 0.79 | GABRA1 (0.46) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341874 | 0.79 | GABRA1 (0.44) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2646554 | 0.79 | GABRG2 (0.39) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341627 | 0.79 | GABRG2 (0.39) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL367826 | 0.79 | GABRG2 (0.41) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915875-B1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-04-09 | — | — | EP | disclosed |