Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002943 | 0.85 | PIK3CG (0.41) | PIK3CGHTR1DHTR3AHTR6TMEM97 | |
| SCHEMBL7003375 | 0.83 | PIM1 (0.47) | PIK3CGMAPK8KDM4EALDH1A1RAB9A | |
| SCHEMBL6993786 | 0.82 | PIK3CG (0.35) | PIK3CGCCNE1CDK2KDM4EALDH1A1 | |
| SCHEMBL7003976 | 0.80 | CDK9 (0.40) | PIK3CGCCNE1CDK2KDM4EALDH1A1 | |
| SCHEMBL7002683 | 0.79 | PRKAB2 (0.41) | PIK3CGCCNE1CDK2 | |
| SCHEMBL7000634 | 0.78 | CDK9 (0.42) | PIK3CGCCNE1CDK2KDM4EALDH1A1 | |
| SCHEMBL7002544 | 0.77 | CDK7 (0.39) | PIK3CGCDK2 | |
| SCHEMBL7003437 | 0.76 | CDK2 (0.44) | PIK3CGHTR1DHTR3AHTR6TMEM97 | |
| SCHEMBL7001327 | 0.76 | CDK7 (0.39) | PIK3CGCDK2 | |
| SCHEMBL7093390 | 0.74 | CDK2 (0.43) | PIK3CGHTR1DHTR3AHTR6TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |