Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.65 |
| ▸ | PDE2A | O00408 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.64 |
| ▸ | PDE6D | O43924 | 1/20 | 0.64 |
| ▸ | PDE8A | O60658 | 1/20 | 0.64 |
| ▸ | PDE9A | O76083 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | PDE6A | P16499 | 1/20 | 0.64 |
| ▸ | PDE6G | P18545 | 1/20 | 0.64 |
| ▸ | PDE4A | P27815 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | PDE6B | P35913 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280616 | 0.88 | PDE5A (0.67) | PDE5AKDM4EPDE3BPDE3APDE2A | |
| SCHEMBL7092377 | 0.86 | PDE5A (0.60) | PDE5AKDM4EPDE3BPDE3APDE2A | |
| Udenafil SCHEMBL30452348 | 0.84 | PDE5A (1.00) | PDE5AKDM4EPDE2APDE9APDE4A | |
| Udenafil SCHEMBL120993 | 0.84 | PDE5A (1.00) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL8233412 | 0.84 | PDE5A (0.78) | PDE5AKDM4EPDE2APDE9APDE4A | |
| SCHEMBL28417921 | 0.83 | PDE5A (0.89) | PDE5APDE3BPDE3APDE2AABCC4 | |
| SCHEMBL7000981 | 0.83 | KDM4E (0.71) | PDE5AKDM4EPDE2AABCC5PDE9A | |
| Udenafil SCHEMBL8066470 | 0.83 | PDE5A (0.83) | PDE5AKDM4EPDE3BPDE3APDE2A | |
| Udenafil SCHEMBL8065455 | 0.83 | PDE5A (0.87) | PDE5AKDM4EPDE2APDE9APDE4A | |
| Udenafil SCHEMBL8066483 | 0.83 | PDE5A (0.83) | PDE5AKDM4EPDE3BPDE3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129093-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCE | DONG A PHARM CO LTD (KR) | 2003-07-23 | — | — | EP | disclosed |