Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.66 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476805 | 0.92 | OPRM1 (0.70) | OPRM1OPRL1SLC6A4DRD2ALDH1A1 | |
| SCHEMBL26996552 | 0.80 | OPRM1 (1.00) | OPRM1OPRL1SLC6A4DRD2ALDH1A1 | |
| SCHEMBL7092767 | 0.79 | OPRM1 (0.45) | OPRM1OPRL1KCNH2OPRD1 | |
| SCHEMBL7091589 | 0.77 | OPRM1 (0.45) | OPRM1OPRL1OPRD1 | |
| SCHEMBL7090555 | 0.74 | OPRL1 (0.66) | OPRM1OPRL1KCNH2OPRD1LMNA | |
| SCHEMBL6211429 | 0.74 | OPRM1 (0.63) | OPRM1OPRL1SLC6A4DRD2ALDH1A1 | |
| SCHEMBL7488668 | 0.73 | OPRM1 (0.62) | OPRM1OPRL1SLC6A4DRD2ALDH1A1 | |
| SCHEMBL11562405 | 0.72 | DRD2 (0.61) | OPRM1OPRL1SLC6A4DRD2ALDH1A1 | |
| SCHEMBL3931858 | 0.72 | DRD2 (0.61) | OPRM1OPRL1SLC6A4DRD2ALDH1A1 | |
| SCHEMBL432010 | 0.72 | DRD2 (0.65) | OPRM1OPRL1SLC6A4DRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030109549-A1 | 2-Substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists | ITO FUMITAKA (JP) | 2003-06-12 | — | — | US | disclosed |
| EP-1102762-B1 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6172067-B1 | ANALGESICS, ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2001-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109549-A1 | 2-Substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists | OPRL1, ORMDL3, OPRM1 | OPRM1 3/4885OPRL1 1/4885SLC6A4 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.