Sugi Predict

Sugi Predict / Compounds / Rosterolone

Rosterolone

Rosterolone

SCHEMBL7094611

CCCC1(O)CC[C@H]2[C@@H]3CCC4CC(=O)CC(C)[C@]4(C)[C@@H]3CC[C@@]21C

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SHBG P04278 6/20 0.57
▸ MAPK1 P28482 2/20 0.45
▸ POLB P06746 1/20 0.45
▸ AR P10275 2/20 0.38
▸ HSD17B3 P37058 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ NR3C1 P04150 2/20 0.36
▸ PGR P06401 2/20 0.36
▸ CYP3A4 P08684 2/20 0.36
▸ HSD17B10 Q99714 2/20 0.36
▸ ABCB11 O95342 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ ADORA3 P0DMS8 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ AGTR1 P30556 1/20 0.36
▸ PTGS2 P35354 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rosterolone SCHEMBL8724124 1.00 SHBG (0.57) SHBGMAPK1POLBARHSD17B3
Rosterolone SCHEMBL141283 1.00 SHBG (0.57) SHBGMAPK1POLBARHSD17B3
SCHEMBL9706258 0.93 SHBG (0.57) SHBGMAPK1POLBARHSD17B3
SCHEMBL9706264 0.93 SHBG (0.57) SHBGMAPK1POLBARHSD17B3
SCHEMBL10408625 0.92 SHBG (0.56) SHBGMAPK1POLBARHSD17B3
SCHEMBL10408627 0.92 SHBG (0.56) SHBGMAPK1POLBARHSD17B3
SCHEMBL10408955 0.91 SHBG (0.55) SHBGMAPK1POLBARHSD17B3
SCHEMBL10408953 0.91 SHBG (0.55) SHBGMAPK1POLBARHSD17B3
SCHEMBL10883090 0.91 SHBG (0.57) SHBGMAPK1POLBARMEN1
SCHEMBL10883085 0.91 SHBG (0.57) SHBGMAPK1POLBARMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4892867-A Antiandrogenic 17-alpha-alkyl steroids SCHERING AKTIENGESELLSCHAFT (DE) 1990-01-09 — — US claimed
EP-0027961-B1 17-ALPHA-SUBSTITUTED STEROIDS, PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR PRODUCTION SCHERING AKTIENGESELLSCHAFT (DE) 1983-01-12 — — EP claimed
EP-0027961-A1 17-alpha-substituted steroids, preparations containing them and process for their production SCHERING AKTIENGESELLSCHAFT (DE) 1981-05-06 — — EP claimed
WO-2003082233-A1 ALLYL-PHENOL COMPOUNDS IN ANDROGENIC DISORDERS GHISALBERTI CARLO (BR) 2003-10-09 — — WO disclosed
US-5798338-A STEROID/BETA-CYCLODEXTRIN CLATHRATE; OXIDATION RESISTANCE SCHERING AKTIENGESELLSCHAFT (DE) 1998-08-25 — — US disclosed
US-5723146-A Pharmaceutical preparations SCHERING AKTIENGESELLSCHAFT (DE) 1998-03-03 — — US disclosed
EP-0218647-B1 SKIN TREATMENT AGENTS SCHERING AKTIENGESELLSCHAFT (DE) 1992-06-17 — — EP disclosed
US-4892867-A Antiandrogenic 17-alpha-alkyl steroids SCHERING AKTIENGESELLSCHAFT (DE) 1990-01-09 — — US disclosed
US-4859659-A ACNE TREATMENT SCHERING AKTIENGESELLSCHAFT (DE) 1989-08-22 — — US disclosed
US-4558041-A ACNE, DEPILATORIES; BALDNESS SCHERING AKTIENGESELLSCHAFT (DE) 1985-12-10 — — US disclosed
US-4456600-A Antiandrogenic 17α-alkyl steroids SCHERING, AKTIENGESELLSCHAFT (A.G.) (DE) 1984-06-26 — — US disclosed
EP-0027961-B1 17-ALPHA-SUBSTITUTED STEROIDS, PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR PRODUCTION SCHERING AKTIENGESELLSCHAFT (DE) 1983-01-12 — — EP disclosed
US-4344941-A Antiandrogenic 17α-substituted steroids SCHERING AKTIENGESELLSCHAFT (A.G.) (DE) 1982-08-17 — — US disclosed