SCHEMBL709478

SCHEMBL709478

Cc1c(CCl)cc2ccc(F)cc2c1OCc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.40
MAPT P10636 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
MAPK1 P28482 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PTGDR2 Q9Y5Y4 3/20 0.39
DHODH Q02127 2/20 0.38
HTR6 P50406 2/20 0.37
KCNH2 Q12809 2/20 0.37
BCHE P06276 2/20 0.36
LMNA P02545 2/20 0.36
POLB P06746 1/20 0.36
STAT3 P40763 1/20 0.36
HTT P42858 1/20 0.36
ALOX5 P09917 1/20 0.36
PKM P14618 1/20 0.36
KDM1A O60341 2/20 0.35
TSHR P16473 1/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL711116 0.88 PTGDR2 (0.41) SMN1; SMN2MAPTL3MBTL1MAPK1TDP1
SCHEMBL27822172 0.84 PTGDR2 (0.55) PTGDR2
SCHEMBL27841427 0.82 ALDH1A1 (0.46) SMN1; SMN2PTGDR2DHODHLMNA
SCHEMBL27823499 0.82 MAPT (0.42) SMN1; SMN2MAPTL3MBTL1MAPK1TDP1
SCHEMBL710337 0.82 PTGDR2 (0.48) PTGDR2DHODHLMNA
SCHEMBL2172169 0.79 DHODH (0.41) SMN1; SMN2MAPTL3MBTL1MAPK1TDP1
SCHEMBL3096755 0.79 DHODH (0.46) SMN1; SMN2MAPTL3MBTL1MAPK1TDP1
SCHEMBL708470 0.76 PLA2G2A (0.51) MAPTL3MBTL1TDP1DHODHLMNA
SCHEMBL27822170 0.76 PTPN1 (0.55) SMN1; SMN2MAPTL3MBTL1MAPK1TDP1
SCHEMBL26731621 0.76 DHODH (0.47) SMN1; SMN2MAPTL3MBTL1MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2791111-B1 [4-(PIPERIDIN-4-YL)-NAPHTHALEN-2-YL]-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS FOR THE TREATMENT OF RESPIRATORY DISORDERS HOFFMANN LA ROCHE (CH) 2017-01-18 EP disclosed
US-9000044-B2 Substituted naphthylacetic acids HOFFMANN-LA ROCHE INC. (US) 2015-04-07 US disclosed
EP-2791111-A1 PIPERIDINYL NAPHTHYLACETIC ACIDS F.HOFFMANN-LA ROCHE AG (CH) 2014-10-22 EP disclosed
US-8642629-B2 Naphthylacetic acids HOFFMANN-LA ROCHE INC. (US) 2014-02-04 US disclosed
US-8642629-B2 Naphthylacetic acids HOFFMANN-LA ROCHE INC. (US) 2014-02-04 US disclosed
US-8642629-B2 Naphthylacetic acids HOFFMANN-LA ROCHE INC. (US) 2014-02-04 US disclosed
EP-2358677-B1 NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS HOFFMANN LA ROCHE (CH) 2014-01-08 EP disclosed
EP-2358677-B1 NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS HOFFMANN LA ROCHE (CH) 2014-01-08 EP disclosed
WO-2013127841-A1 SUBSTITUTED NAPHTHYLACETIC ACIDS F. HOFFMANN-LA ROCHE AG (CH) 2013-09-06 WO disclosed
US-20130225588-A1 SUBSTITUTED NAPHTHYLACETIC ACIDS HOFFMANN-LA ROCHE INC. (US) 2013-08-29 US disclosed
US-20100125061-A1 NAPHTHYLACETIC ACIDS FIROOZNIA FARIBORZ 2010-05-20 US disclosed
US-20100125061-A1 NAPHTHYLACETIC ACIDS FIROOZNIA FARIBORZ 2010-05-20 US disclosed
US-20100125061-A1 NAPHTHYLACETIC ACIDS FIROOZNIA FARIBORZ 2010-05-20 US disclosed
WO-2010055004-A1 NAPHTHYLACETIC ACIDS F. HOFFMANN-LA ROCHE AG (CH) 2010-05-20 WO disclosed
WO-2010055004-A1 NAPHTHYLACETIC ACIDS F. HOFFMANN-LA ROCHE AG (CH) 2010-05-20 WO disclosed
US-20100125058-A1 NAPHTHYLACETIC ACIDS CHEN LI 2010-05-20 US disclosed
US-20100125058-A1 NAPHTHYLACETIC ACIDS CHEN LI 2010-05-20 US disclosed
US-20100125058-A1 NAPHTHYLACETIC ACIDS CHEN LI 2010-05-20 US disclosed
WO-2010055006-A1 NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2010-05-20 WO disclosed
WO-2010055006-A1 NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2010-05-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100125058-A1 NAPHTHYLACETIC ACIDS HRH2, HRH1, HRH3 SMN1; SMN2 4014/4885MAPT 4671/4885L3MBTL1 4726/4885
US-20100125061-A1 NAPHTHYLACETIC ACIDS HRH2, HRH1, HRH3 SMN1; SMN2 3890/4885MAPT 4646/4885L3MBTL1 4773/4885
US-20130225588-A1 SUBSTITUTED NAPHTHYLACETIC ACIDS HRH2, HRH1, HRH3 SMN1; SMN2 3690/4885MAPT 4495/4885L3MBTL1 4824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.