Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14793009 | 0.96 | LMNA (0.48) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL9735193 | 0.94 | LMNA (0.46) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL8858996 | 0.86 | LMNA (0.47) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL9735042 | 0.86 | LMNA (0.47) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL24217645 | 0.86 | LMNA (0.52) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL9293485 | 0.82 | LMNA (0.44) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL9736602 | 0.80 | TDP2 (0.33) | LMNACYP2C19HIF1ABCHEACHE | |
| SCHEMBL14790182 | 0.79 | LMNA (0.46) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL9736416 | 0.79 | LMNA (0.41) | LMNACYP2C19HIF1A | |
| SCHEMBL9581262 | 0.77 | LMNA (0.57) | LMNACYP2C19HIF1AEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133466-B1 | A PROCESS FOR THE PREPARATION OF N,N'-BIS 2, 3-DIHYDROXYPROPYL] -5-[(HYDROXYACETYL) METHYLAMINO]-2, 4,6-TRIIODO-1, 3-BENZENEDI CARBOXAMIDE | BRACCO INT BV (NL) | 2003-08-20 | — | — | EP | disclosed |
| US-6420603-B1 | ESTERIFICATION OF 5-HYDROXYISOPHTHALIC ACID, AMIDATION WITH ISOSERINOL, IODINATION AND ALKYLATION | BRACCO INTERNATIONAL B.V. (NL) | 2002-07-16 | — | — | US | disclosed |