Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.60 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.60 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.53 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.45 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL1200041 | 1.00 | EGLN1 (0.60) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL7194377 | 1.00 | EGLN1 (0.60) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL7752291 | 1.00 | EGLN1 (0.60) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL6421948 | 0.91 | EGLN1 (0.50) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL28609907 | 0.89 | LMNA (0.48) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Glutarate SCHEMBL6333785 | 0.88 | SLC22A6 (0.65) | LMNAABCC4MAPTOR51E2SLC22A6 | |
| Adipic Acid SCHEMBL6402459 | 0.88 | LMNA (0.65) | LMNAABCC4MAPTOR51E2SLC22A6 | |
| Adipic Acid SCHEMBL874846 | 0.88 | LMNA (0.65) | LMNAABCC4MAPTOR51E2SLC22A6 | |
| Sebacic Acid SCHEMBL7054977 | 0.85 | TSHR (0.67) | LMNAABCC4MAPTOR51E2SLC22A6 | |
| Propene SCHEMBL7058438 | 0.85 | TSHR (0.67) | LMNAABCC4MAPTOR51E2SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334172-A1 | MACHINING FLUID AND METHOD OF MACHINING | Milacron Inc. (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002061022-A1 | MACHINING FLUID AND METHOD OF MACHINING | MILACRON INC. (US) | 2002-08-08 | — | — | WO | disclosed |
| US-6316394-B1 | SULFURIZED ORGANIC LUBRICANTS AND HALOGENATED ORGANIC LUBRICANTS | MILACRON INC. | 2001-11-13 | — | — | US | disclosed |
| US-5704961-A | MONOCARBOXYLIC ACIDS, POLYCARBOXYLIC ACIDS OR THEIR SALTS | HUDSON ALICE P (US) | 1998-01-06 | — | — | US | disclosed |
| US-4448586-A | ALKYL OR ALKENYL SUCCINIC ACID AND ANESTER THEREOF, A GLYCOL, AND A DIMER OR TRIMER ACID | ETHYL CORPORATION (US) | 1984-05-15 | — | — | US | disclosed |