SCHEMBL709538

SCHEMBL709538

CCc1[c]c(CC)c(Cl)cc1Cl

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.32
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
GRIN3A Q8TCU5 1/20 0.31
MAPK1 P28482 1/20 0.30
AHR P35869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15064040 0.72 ALDH1A1 (0.32)
SCHEMBL5581285 0.71
SCHEMBL10691257 0.70
SCHEMBL11417421 0.70 CYP2A6 (0.36)
SCHEMBL15064036 0.69
SCHEMBL3689561 0.69 CYP3A4 (0.31) CYP3A4
SCHEMBL512915 0.67
SCHEMBL11784137 0.64
SCHEMBL11219358 0.63 GRIN2D (0.52) CYP3A4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL14143885 0.63 HPGD (0.48) CYP3A4GRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1125979-B1 Polymer blends INEOS EUROPE LTD (GB) 2006-11-29 EP claimed
CN-1216079-C Polymersation catalysts BP CHEM INT LTD (GB) 2005-08-24 CN claimed
US-6828398-B2 Transition metal complex containing pyrimidine or pyrazine compound used as polymerization catalysts for alpha-olefins BP CHEMICALS LIMITED (GB) 2004-12-07 US claimed
EP-1062250-B1 POLYMERISATION CATALYSTS BP CHEM INT LTD (GB) 2004-07-14 EP claimed
US-6608140-B2 Polymer blends BP CHEMICALS LIMITED (GB) 2003-08-19 US claimed
US-20030100689-A1 Polymerisation catalyst BP CHEMICALS LIMITED (GB) 2003-05-29 US claimed
EP-1265935-A1 POLYMERISATION CATALYST BP Chemicals Limited (GB) 2002-12-18 EP claimed
EP-1102777-B1 PREPARATION OF POLYMERISATION CATALYSTS BP CHEM INT LTD (GB) 2002-12-18 EP claimed
EP-1015501-B1 POLYMERISATION CATALYSTS BP CHEM INT LTD (GB) 2002-05-29 EP claimed
US-20020004560-A1 Polymer blends INEOS SALES (UK) LIMITED (GB) 2002-01-10 US claimed
WO-2001068726-A1 ATOM TRANSFER RADICAL POLYMERISATION CATALYST BP CHEMICALS LIMITED (GB) 2001-09-20 WO claimed
EP-1125979-A1 Polymer blends BP Chemicals Limited (GB) 2001-08-22 EP claimed
WO-2001058966-A1 POLYMERISATION CATALYST BP CHEMICALS LIMITED (GB) 2001-08-16 WO claimed
WO-2001012684-A1 POLYMERISATION PROCESS BP CHEMICALS LIMITED (GB) 2001-02-22 WO claimed
WO-2000069869-A1 POLYMERISATION CATALYSTS BP CHEMICALS LIMITED (GB) 2000-11-23 WO claimed
WO-2000058320-A1 PYRIDINE.IMINE POLYMERISATION CATALYSTS BP CHEMICALS LIMITED (GB) 2000-10-05 WO claimed
EP-2308815-B1 CHAIN GROWTH REACTION PROCESS INEOS SALES UK LTD (GB) 2018-11-14 EP disclosed
EP-1910426-B1 DIENE POLYMERISATION INEOS SALES (UK) LTD (GB) 2018-01-03 EP disclosed
EP-1062250-A1 POLYMERISATION CATALYSTS BP Chemicals Limited (GB) 2000-12-27 EP disclosed
WO-1999046303-A1 POLYMERISATION CATALYSTS BP CHEMICALS LIMITED (GB) 1999-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030100689-A1 Polymerisation catalyst NR1H2, NR1H3, MT-CO1 CYP3A4 564/4885GRIN2D 1493/4885GRIN3B 942/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.