Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | BID | P55957 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067339 | 0.91 | BCL2 (0.55) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL20742924 | 0.85 | SRD5A2 (0.60) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL31159405 | 0.85 | BCL2 (0.66) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL7065914 | 0.83 | ALDH1A1 (0.58) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL20761835 | 0.83 | BCL2 (0.58) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL6866199 | 0.82 | HDAC3 (0.69) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL31159349 | 0.81 | NOD2 (0.61) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL20753214 | 0.81 | SRD5A2 (0.55) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL31159493 | 0.81 | SRD5A2 (0.55) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL31159364 | 0.81 | HDAC1 (0.62) | HDAC1HDAC6HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553075-B1 | LPA RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO (JP) | 2013-08-14 | — | — | EP | disclosed |
| EP-2565178-A1 | LPA Receptor Antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20120088782-A1 | LPA RECEPTOR ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-04-12 | — | — | US | disclosed |
| US-8124645-B2 | LPA receptor antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-7820682-B2 | LPA receptor antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-10-26 | — | — | US | disclosed |
| US-20100249157-A2 | LPA RECEPTOR ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-30 | — | — | US | disclosed |
| US-20080293764-A1 | LPA RECEPTOR ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. | 2008-11-27 | — | — | US | disclosed |
| US-20060148830-A1 | Lpa receptor antagonist | ONO PHARMACEUTICAL CO., LTD. | 2006-07-06 | — | — | US | disclosed |
| EP-1553075-A1 | LPA RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293764-A1 | LPA RECEPTOR ANTAGONIST | LPAR1, LPAR2, LPAR4 | HDAC1 983/4885HDAC6 808/4885HDAC3 1505/4885 |
| US-20100249157-A2 | LPA RECEPTOR ANTAGONIST | LPAR1, LPAR2, LPAR4 | HDAC1 983/4885HDAC6 808/4885HDAC3 1505/4885 |
| US-20120088782-A1 | LPA RECEPTOR ANTAGONIST | LPAR1, LPAR2, LPAR4 | HDAC1 983/4885HDAC6 808/4885HDAC3 1505/4885 |
| US-20060148830-A1 | Lpa receptor antagonist | LPAR1, LPAR2, LPAR4 | HDAC1 983/4885HDAC6 808/4885HDAC3 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.