Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11657337 | 0.82 | PDK1 (0.54) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL24187914 | 0.77 | PDK1 (0.55) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL4867823 | 0.77 | KMT2A (0.51) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL677655 | 0.76 | MAPK1 (0.55) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL13729342 | 0.75 | KMT2A (0.53) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL2312212 | 0.74 | NPSR1 (0.50) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL10359712 | 0.74 | MAPK1 (0.53) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL24202393 | 0.74 | NPSR1 (0.47) | MAPTNPSR1PDK1PDK2PDK3 | |
| SCHEMBL23123715 | 0.74 | NPSR1 (0.60) | MAPTMAPK1TDP1L3MBTL1NPSR1 | |
| SCHEMBL8758916 | 0.74 | RAB9A (0.46) | MAPTTDP1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337550-A2 | HEPATITIS C TRIPEPTIDE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002060926-A2 | HEPATITIS C TRIPEPTIDE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |