Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 2/20 | 0.62 |
| ▸ | ABCC9 | O60706 | 15/20 | 0.53 |
| ▸ | KCNJ11 | Q14654 | 15/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 11/20 | 0.53 |
| ▸ | KCNJ8 | Q15842 | 11/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099811 | 0.85 | ABCC9 (0.53) | CACNA1CABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7144692 | 0.83 | KDM4E (0.64) | CACNA1CKDM4EALDH1A1LMNA | |
| SCHEMBL31069038 | 0.82 | MAPT (0.63) | CACNA1CKDM4EALDH1A1LMNACACNA1F | |
| SCHEMBL9636791 | 0.82 | MAPT (0.63) | CACNA1CKDM4EALDH1A1LMNACACNA1F | |
| SCHEMBL11255190 | 0.81 | CACNA1C (0.53) | CACNA1CLMNACACNA1FADORA3CACNA1D | |
| SCHEMBL10725299 | 0.80 | KDM4E (0.71) | CACNA1CKDM4EALDH1A1LMNACACNA1F | |
| SCHEMBL6928301 | 0.80 | ABCC9 (0.50) | CACNA1CABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL11007384 | 0.80 | MEN1 (0.62) | CACNA1CKDM4EALDH1A1LMNACACNA1F | |
| SCHEMBL9837396 | 0.80 | CACNA1C (0.50) | CACNA1CKDM4EALDH1A1LMNACACNA1F | |
| SCHEMBL31069039 | 0.79 | CACNA1F (0.60) | CACNA1CKDM4EALDH1A1LMNACACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |