Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 15/20 | 0.58 |
| ▸ | KCNJ11 | Q14654 | 15/20 | 0.58 |
| ▸ | ABCC8 | Q09428 | 11/20 | 0.58 |
| ▸ | KCNJ8 | Q15842 | 11/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099312 | 0.85 | ABCC9 (0.62) | ABCC9KCNJ11ABCC8KCNJ8KDM4E | |
| SCHEMBL7097001 | 0.85 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8KDM4E | |
| SCHEMBL7101255 | 0.85 | ABCC9 (0.66) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7099662 | 0.85 | MAPT (0.61) | KDM4EALDH1A1LMNAGAAMAPT | |
| SCHEMBL7099723 | 0.81 | ABCC9 (0.61) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7096606 | 0.81 | ABCC9 (0.54) | ABCC9KCNJ11ABCC8KCNJ8KDM4E | |
| SCHEMBL7098806 | 0.81 | ABCC9 (0.65) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL10830997 | 0.81 | ALDH1A1 (0.74) | ABCC9KCNJ11ABCC8KCNJ8KDM4E | |
| SCHEMBL7099811 | 0.80 | ABCC9 (0.53) | ABCC9KCNJ11ABCC8KCNJ8KDM4E | |
| SCHEMBL27156931 | 0.79 | ALDH1A1 (0.58) | ABCC9KCNJ11ABCC8KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |