Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217455 | 0.85 | CCR5 (0.71) | CCR5ALDH1A1NPSR1HPGDKDM4E | |
| SCHEMBL8873985 | 0.81 | KDM4E (0.50) | CCR5ALDH1A1NPSR1POLBKDM4E | |
| SCHEMBL11140353 | 0.81 | TSHR (0.54) | ALDH1A1HPGDPOLBKDM4ETDP1 | |
| SCHEMBL2277814 | 0.80 | TDP1 (0.54) | CCR5ALDH1A1NPSR1KDM4ETDP1 | |
| SCHEMBL19381651 | 0.80 | CCR5 (0.64) | CCR5ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL11030895 | 0.77 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL27542208 | 0.76 | KDM4E (0.74) | CCR5ALDH1A1POLBKDM4ETDP1 | |
| SCHEMBL23064593 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL10805919 | 0.73 | ALDH1A1 (0.43) | ALDH1A1NPSR1HPGDPOLBKDM4E | |
| SCHEMBL13419199 | 0.73 | POLB (0.52) | ALDH1A1POLBKDM4ESMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979076-A4 | INTERMEDIATES AND PROCESSES FOR PREPARING BENZO b]THIOPHENES | LILLY CO ELI (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-0979076-A1 | INTERMEDIATES AND PROCESSES FOR PREPARING BENZO b]THIOPHENES | ELI LILLY AND COMPANY (US) | 2000-02-16 | — | — | EP | disclosed |
| US-6018056-A | Intermediates and processes for preparing benzo (b) thiophenes | ELI LILLY AND COMPANY (US) | 2000-01-25 | — | — | US | disclosed |
| WO-1998048793-A1 | INTERMEDIATES AND PROCESSES FOR PREPARING BENZO[b]THIOPHENES | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |