Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.65 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.65 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | PRKACG | P22612 | 1/20 | 0.50 |
| ▸ | PRKACB | P22694 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | PRKCH | P24723 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30608285 | 1.00 | IMPDH2 (0.65) | IMPDH2IMPDH1SIRT2CDK4PRKD3 | |
| SCHEMBL31264046 | 1.00 | IMPDH2 (0.65) | IMPDH2IMPDH1SIRT2CDK4PRKD3 | |
| SCHEMBL28903106 | 0.81 | EGFR (0.46) | IMPDH2IMPDH1CDK4NR4A2ALDH1A1 | |
| SCHEMBL28485389 | 0.81 | PTGES (0.51) | IMPDH2IMPDH1CDK4CCNB2CCNE2 | |
| SCHEMBL28479715 | 0.81 | MEN1 (0.44) | IMPDH2IMPDH1NR4A2MAPTMEN1 | |
| SCHEMBL28479667 | 0.81 | CSNK2A1 (0.52) | IMPDH2IMPDH1CCNB2CDK1PIM1 | |
| SCHEMBL7096071 | 0.81 | IMPDH2 (0.49) | IMPDH2IMPDH1PRKCQPRKCD | |
| SCHEMBL20562470 | 0.80 | IMPDH2 (0.57) | IMPDH2IMPDH1SIRT2CDK4PRKD3 | |
| SCHEMBL1202543 | 0.80 | IMPDH2 (0.63) | IMPDH2IMPDH1SIRT2CDK4PRKD3 | |
| SCHEMBL186741 | 0.79 | IMPDH2 (1.00) | IMPDH2IMPDH1SIRT2CDK4PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111793069-B | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2021-05-18 | — | — | CN | disclosed |
| CN-111793069-B | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2021-05-18 | — | — | CN | disclosed |
| CN-111793069-A | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2020-10-20 | — | — | CN | disclosed |
| CN-111793069-A | Method for efficiently preparing fused ring compound containing indole structural unit | 清华大学 | 2020-10-20 | — | — | CN | disclosed |
| EP-2350090-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010045251-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS, INC. (CA) | 2010-04-22 | — | — | WO | disclosed |