Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239569 | 0.80 | KDM4E (0.49) | MAPTSMN1; SMN2TP53ALDH1A1MEN1 | |
| SCHEMBL6724869 | 0.79 | TRPA1 (0.54) | MAPTSMN1; SMN2TP53ALDH1A1MEN1 | |
| SCHEMBL6256414 | 0.79 | MAPT (0.47) | MAPTSMN1; SMN2TP53ALDH1A1KDM4E | |
| SCHEMBL7031009 | 0.77 | MAPT (0.63) | MAPTTP53ALDH1A1MEN1KMT2A | |
| SCHEMBL6254956 | 0.77 | MAPT (0.56) | MAPTTP53MALT1ALDH1A1KDM4E | |
| SCHEMBL6237897 | 0.74 | KDM4E (0.45) | MAPTSMN1; SMN2ALDH1A1TSHRKDM4E | |
| SCHEMBL6254208 | 0.71 | KDM4E (0.43) | MAPTSMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL6253952 | 0.71 | MAPT (0.48) | MAPTTP53ALDH1A1PKMTSHR | |
| SCHEMBL6727884 | 0.71 | TRPA1 (0.54) | MAPTTP53 | |
| SCHEMBL6237834 | 0.70 | HSD17B10 (0.45) | MAPTALDH1A1TSHRKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |