Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096998 | 1.00 | GAA (0.42) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL7902399 | 0.89 | ALDH1A1 (0.40) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL7902401 | 0.89 | ALDH1A1 (0.40) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL7910651 | 0.88 | GAA (0.43) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL7910653 | 0.88 | GAA (0.43) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL18414121 | 0.82 | GAA (0.42) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL14223151 | 0.79 | GAA (0.40) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL7455128 | 0.78 | KMT2A (0.55) | GAANFKB1NFKB2RELAKMT2A | |
| SCHEMBL15199925 | 0.77 | GAA (0.45) | GAANFKB1NFKB2RELAF2 | |
| SCHEMBL17236211 | 0.77 | GAA (0.39) | GAANFKB1NFKB2RELAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229910-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-1229910-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2002-08-14 | — | — | EP | disclosed |
| US-6413955-B1 | 1,8-NAPHTHYRIDINES OR 5-THIO-1,8-NAPHTHYRIDINES OR 5-OXO-1,8-NAPHTHYRIDINES; BONE RESORPTION, OSTEOPOROSIS, VASCULAR REST-ENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIO-GENESIS, ATHEROSCLEROSIS, INFLAMMATORY ARTHRITIS, CANCER | MERCK & CO., INC. | 2002-07-02 | — | — | US | disclosed |
| WO-2001024797-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2001-04-12 | — | — | WO | disclosed |