Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 13/20 | 0.68 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.53 |
| ▸ | CCKBR | P32239 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005683 | 1.00 | OXTR (0.68) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6005069 | 0.87 | OXTR (0.68) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6005661 | 0.86 | OXTR (0.70) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6003636 | 0.86 | OXTR (0.65) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6005694 | 0.85 | OXTR (0.60) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6003771 | 0.82 | CCKBR (0.68) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6005678 | 0.79 | OXTR (0.56) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6005007 | 0.77 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6006404 | 0.77 | PSEN1 (0.78) | OXTRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6005723 | 0.77 | PSEN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |