SCHEMBL7097802

SCHEMBL7097802

CNN1CCC[C@H](c2cncc(C#N)c2)CC1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 3/20 0.43
CHRNB4 P30926 3/20 0.43
CHRNA3 P32297 3/20 0.43
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43
CHRNG P07510 1/20 0.43
CHRNB1 P11230 1/20 0.43
CHRND Q07001 1/20 0.43
CHRNA2 Q15822 1/20 0.43
DRD3 P35462 7/20 0.40
DRD2 P14416 6/20 0.40
CYP2D6 P10635 1/20 0.37
TSHR P16473 1/20 0.37
NFKB1 P19838 1/20 0.37
CASP1 P29466 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
FASN P49327 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7099363 1.00 CHRNA1 (0.43) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7098422 0.90 DRD3 (0.45) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7102434 0.87 CHRNA3 (0.59) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7102601 0.87 CHRNA3 (0.59) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7101838 0.87 CHRNB4 (0.39) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7102542 0.87 CHRNB4 (0.39) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7102539 0.86 DRD3 (0.41) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7099140 0.86 DRD3 (0.41) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7098836 0.80 RIPK1 (0.39) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL21037715 0.79 CHRNB4 (0.43) CHRNA1CHRNB4CHRNA3CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed