Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CPS1 | P31327 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14637537 | 0.87 | KMT2A (0.62) | HSD11B1LMNAKMT2AMGLLHSD17B10 | |
| SCHEMBL4232496 | 0.86 | HSD11B1 (0.64) | HSD11B1LMNAKMT2AHTR2AGRM2 | |
| SCHEMBL7094262 | 0.85 | HSD11B1 (0.47) | HSD11B1LMNAKMT2AHTR2AGRM2 | |
| SCHEMBL2956024 | 0.84 | HSD11B1 (0.52) | HSD11B1LMNAKMT2AHTR2AGRM2 | |
| SCHEMBL17938078 | 0.76 | HSD11B1 (0.60) | HSD11B1KMT2AMGLLHTTCPS1 | |
| SCHEMBL16446727 | 0.74 | ALDH1A1 (0.56) | HSD11B1LMNAKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL10954882 | 0.74 | KAT6A (0.52) | LMNAKMT2AHSD17B10ALDH1A1HTT | |
| SCHEMBL13220728 | 0.73 | STS (0.48) | HSD11B1LMNAKMT2AALDH1A1 | |
| SCHEMBL13701329 | 0.72 | HTR2A (0.57) | HSD11B1LMNAKMT2AHTR2AGRM2 | |
| SCHEMBL13701275 | 0.72 | HTR2A (0.71) | HSD11B1LMNAKMT2AHTR2AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1361875-A2 | NOVEL HETEROCYCLIC AMIDE DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | Aventis Pharmaceuticals Inc. (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066469-A2 | NOVEL HETEROCYCLIC AMIDE DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMACEUTICALS INC. (US) | 2002-08-29 | — | — | WO | disclosed |