Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100414 | 0.96 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM3 | |
| Hydrochloric Acid SCHEMBL7101517 | 0.95 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM3 | |
| Hydrochloric Acid SCHEMBL7101891 | 0.95 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM3 | |
| Bromide SCHEMBL7100454 | 0.95 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM3 | |
| Fumaric Acid SCHEMBL7957765 | 0.94 | HTR7 (0.44) | HTR7HTR1ADRD2HTR6CHRM3 | |
| SCHEMBL7103677 | 0.85 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| SCHEMBL7097662 | 0.85 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| SCHEMBL7097626 | 0.85 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| SCHEMBL7099289 | 0.85 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| Hydrochloric Acid SCHEMBL7097386 | 0.85 | BCL2 (0.47) | HTR7BCL2BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020443-B1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | AZWELL INC (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-6172228-B1 | Process for producing piperazinesulfonamide derivatives and salts thereof | AZWELL INC. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-1020443-A1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | Azwell Inc. (JP) | 2000-07-19 | — | — | EP | disclosed |