Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 7/20 | 0.44 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.41 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.37 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 9/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 2/20 | 0.38 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7097833 | 0.94 | HTR7 (0.46) | HTR7HTR1ADRD2HTR6CHRM1 | |
| SCHEMBL7100414 | 0.93 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM1 | |
| Bromide SCHEMBL7100454 | 0.92 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM1 | |
| Hydrochloric Acid SCHEMBL7101891 | 0.92 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM1 | |
| Hydrochloric Acid SCHEMBL7101517 | 0.92 | HTR7 (0.47) | HTR7HTR1ADRD2HTR6CHRM1 | |
| SCHEMBL7103677 | 0.83 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| SCHEMBL7099289 | 0.83 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| SCHEMBL7097626 | 0.83 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| SCHEMBL7097662 | 0.83 | BCL2 (0.48) | HTR7BCL2BAK1 | |
| Hydrochloric Acid SCHEMBL7097386 | 0.82 | BCL2 (0.47) | HTR7BCL2BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172228-B1 | Process for producing piperazinesulfonamide derivatives and salts thereof | AZWELL INC. (JP) | 2001-01-09 | — | — | US | disclosed |