Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759098 | 0.84 | LDHA (0.58) | TDP1KDM4EERN1MAPKAPK2NPC1 | |
| SCHEMBL12647230 | 0.82 | NPC1 (0.44) | KDM4EERN1MAPKAPK2NPC1RAB9A | |
| SCHEMBL12664063 | 0.79 | ERN1 (0.43) | KDM4EHTTERN1MAPKAPK2NPC1 | |
| SCHEMBL10565122 | 0.79 | KDM4E (0.51) | KDM4EHTTERN1MAPKAPK2NPC1 | |
| SCHEMBL4040801 | 0.77 | KDM4E (0.55) | SIRT3TDP1KDM4EHTTMAPKAPK2 | |
| SCHEMBL5800959 | 0.77 | SIRT3 (0.56) | SIRT3TDP1KDM4EHTTERN1 | |
| SCHEMBL29900258 | 0.75 | KDM4E (0.57) | SIRT3TDP1KDM4EHTTERN1 | |
| SCHEMBL356272 | 0.74 | LDHA (0.69) | KDM4EHTTNPC1RAB9ACYP1A1 | |
| SCHEMBL7843617 | 0.74 | IMPDH2 (0.61) | KDM4EHTTERN1MAPKAPK2CACNA1B | |
| SCHEMBL9827957 | 0.74 | ERN1 (0.59) | KDM4EHTTERN1MAPKAPK2CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562822-B2 | Heterocyle carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |
| EP-1299360-A2 | HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-04-09 | — | — | EP | disclosed |
| US-20020188004-A1 | Heterocycle carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-12-12 | — | — | US | disclosed |
| WO-2002004422-A2 | HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |
| US-4812565-A | ANTIHISTAMINE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-14 | — | — | US | disclosed |
| US-4810795-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| US-4727152-A | Intermediates useful in the preparation of fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1988-02-23 | — | — | US | disclosed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4642343-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | disclosed |
| US-4592866-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188004-A1 | Heterocycle carboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, HDAC1 | SIRT3 68/4885TDP1 1534/4885KDM4E 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.