Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HAAO | P46952 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 4/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.34 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.34 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669707 | 0.74 | NOTUM (0.48) | NOTUMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL969676 | 0.74 | NOTUM (0.39) | NOTUMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL22289924 | 0.68 | ALDH1A1 (0.38) | NOTUMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9611418 | 0.68 | NOTUM (0.50) | NOTUMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL29131835 | 0.66 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDMEN1POLB | |
| SCHEMBL6915834 | 0.65 | KDM4E (0.47) | NOTUMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9562901 | 0.65 | NOTUM (0.38) | NOTUMALDH1A1KDM4EHSD17B10GABRP | |
| SCHEMBL70135 | 0.64 | KDM4E (0.54) | NOTUMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL235710 | 0.64 | KDM4E (0.54) | NOTUMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11362906 | 0.64 | BAZ2B (0.46) | NOTUMALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |