Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093421 | 0.91 | ALDH1A1 (0.71) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL9416927 | 0.90 | ALDH1A1 (0.73) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL7098425 | 0.86 | SIGMAR1 (0.50) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL9417005 | 0.84 | ALDH1A1 (0.85) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL25435385 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL30545315 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL9417065 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL9734301 | 0.81 | ALDH1A1 (0.66) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL9734467 | 0.80 | ALDH1A1 (0.68) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL9417094 | 0.80 | ALDH1A1 (0.90) | ALDH1A1KDM4EMAPTTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901469-B1 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | UNIV MONASH (AU) | 2003-08-27 | — | — | EP | disclosed |
| US-6232314-B1 | SUCH AS 1-(2-(4-CHLOROPHENYL)-2-HYDROXY)ETHYL-4-(3,5-BIS(1,1-DIMETHYLETHYL)-4 -HYDROXYPHENYL)METHYLPIPERAZINE; USED TO TREAT STROKE, CARDIAC ARREST, ISCHAEMIA, HYPOXIA, HYPOGLYCAEMIA, EPILEPSY, AND AMYOTROPHIC LATERAL SCLEROSIS | MONASH UNIVERSITY (AU) | 2001-05-15 | — | — | US | disclosed |
| EP-0901469-A4 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | UNIV MONASH (AU) | 2000-11-15 | — | — | EP | disclosed |
| EP-0901469-A1 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | MONASH UNIVERSITY (AU) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043259-A1 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | MONASH UNIVERSITY (AU) | 1997-11-20 | — | — | WO | disclosed |