Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7595472 | 0.98 | CHRNB4 (0.35) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL8506591 | 0.88 | CHRNB2 (0.42) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6233084 | 0.81 | CHRNB2 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7668971 | 0.81 | CHRNB2 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7411409 | 0.81 | CHRNB4 (0.36) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL4962971 | 0.81 | CHRNB2 (0.49) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL7406929 | 0.81 | CHRNB4 (0.36) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL8550383 | 0.79 | GPR119 (0.37) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6698315 | 0.79 | CHRNB2 (0.55) | CHRNB4CHRNA3CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL8507102 | 0.78 | AKT1 (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500393-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | claimed |