Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105681 | 0.82 | HSD17B10 (0.40) | THRBFGFR1ALDH1A1HTTRPS6KA5 | |
| SCHEMBL5514859 | 0.77 | TDP1 (0.40) | THRBTDP1PIK3CDPIK3CARPS6KB1 | |
| SCHEMBL1624941 | 0.76 | TDP1 (0.39) | TDP1PIK3CDPIK3CARPS6KB1ALDH1A1 | |
| SCHEMBL1626194 | 0.76 | ALDH1A1 (0.40) | THRBTDP1PIK3CDPIK3CARPS6KB1 | |
| SCHEMBL1625307 | 0.76 | TAAR1 (0.41) | TDP1FGFR1PIK3CDPIK3CARPS6KB1 | |
| SCHEMBL6425555 | 0.76 | — | — | |
| SCHEMBL7095653 | 0.72 | KDM4E (0.33) | ALDH1A1POLB | |
| SCHEMBL540748 | 0.66 | THRB (0.64) | THRBTDP1FGFR1PIK3CDPIK3CA | |
| SCHEMBL27600071 | 0.65 | PDE10A (0.40) | TDP1FGFR1CYP1A2ALDH1A1PDE10A | |
| SCHEMBL2326932 | 0.64 | ALDH1A1 (0.59) | FGFR1RPS6KB1ALDH1A1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |