Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14432052 | 0.96 | EPHX1 (0.39) | EPHX1SLC6A2SLC6A4SLC6A3HCRTR2 | |
| Hydrochloric Acid SCHEMBL22389973 | 0.95 | EPHX1 (0.38) | EPHX1SLC6A2SLC6A4SLC6A3HCRTR2 | |
| SCHEMBL8383866 | 0.91 | HCRTR2 (0.38) | EPHX1HCRTR2MEN1KMT2AALDH1A1 | |
| SCHEMBL4505641 | 0.83 | HCRTR2 (0.40) | EPHX1HCRTR2MEN1KMT2AALDH1A1 | |
| SCHEMBL22532010 | 0.81 | HCRTR2 (0.42) | EPHX1HCRTR2MEN1KMT2AALDH1A1 | |
| SCHEMBL6506626 | 0.80 | EPHX1 (0.45) | EPHX1HCRTR2MEN1KMT2AALDH1A1 | |
| SCHEMBL8926365 | 0.78 | HCRTR2 (0.41) | EPHX1HCRTR2MEN1KMT2AALDH1A1 | |
| SCHEMBL9873266 | 0.77 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3ALDH1A1IRAK4 | |
| SCHEMBL9873273 | 0.77 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3ALDH1A1IRAK4 | |
| SCHEMBL2670305 | 0.75 | PSEN1 (0.40) | EPHX1SLC6A2SLC6A4SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11696916-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | MERCK PATENT GMBH (DE) | 2023-07-11 | — | — | US | disclosed |
| EP-3935049-A1 | CARBOXAMIDE-PYRIMIDINE DERIVATIVES AS SHP2 ANTAGONISTS | Merck Patent GmbH (DE) | 2022-01-12 | — | — | EP | disclosed |
| CN-113795483-A | Carboxamide-pyrimidine derivatives as SHP2 antagonists | 默克专利有限公司 | 2021-12-14 | — | — | CN | disclosed |
| US-11033547-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | MERCK PATENT GMBH (DE) | 2021-06-15 | — | — | US | disclosed |
| US-20200281926-A1 | CARBOXAMIDE-PYRIMIDINE DERIVATIVES AS SHP2 ANTAGONISTS | MERCK PATENT GMBH (DE) | 2020-09-10 | — | — | US | disclosed |
| US-20030114666-A1 | Having quinazolindione core structure; non-antibiotic resistance | WARNER-LAMBERT COMPANY | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114666-A1 | Having quinazolindione core structure; non-antibiotic resistance | ABCC1, RPS6KA1, SIGMAR1 | EPHX1 3869/4885SLC6A2 2019/4885SLC6A4 1994/4885 |
| US-11696916-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | PTPN5, PTPN2, PTPN1 | EPHX1 2104/4885SLC6A2 4629/4885SLC6A4 4485/4885 |
| US-11033547-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | PTPN5, PTPN2, PTPN1 | EPHX1 2104/4885SLC6A2 4629/4885SLC6A4 4485/4885 |
| US-20200281926-A1 | CARBOXAMIDE-PYRIMIDINE DERIVATIVES AS SHP2 ANTAGONISTS | PTPN5, PTPN2, PTPN1 | EPHX1 2104/4885SLC6A2 4629/4885SLC6A4 4485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.