Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27600071 | 0.81 | PDE10A (0.40) | PDE10ACYP1A2HPGDALDH1A1 | |
| SCHEMBL27599854 | 0.81 | ALDH1A1 (0.51) | PDE10ACRBNCYP1A2ALDH1A1NPC1 | |
| SCHEMBL28754629 | 0.81 | PDE10A (0.40) | ESR1ESR2SMN1; SMN2PDE10ACRBN | |
| SCHEMBL27600130 | 0.81 | PDE10A (0.40) | PDE10ACYP1A2HPGDALDH1A1RAB9A | |
| SCHEMBL27618382 | 0.79 | PDE10A (0.38) | ESR1ESR2PDE10ACYP1A2ALDH1A1 | |
| SCHEMBL27599860 | 0.79 | PDE10A (0.39) | PDE10ACYP1A2HSD17B10PPARGALDH1A1 | |
| SCHEMBL27600144 | 0.79 | MAPK1 (0.46) | SMN1; SMN2PDE10APOLBCYP1A2HPGD | |
| SCHEMBL7097864 | 0.78 | CNR2 (0.41) | PDE10ACYP1A2HSD17B10 | |
| SCHEMBL7099453 | 0.77 | NR1H2 (0.42) | SMN1; SMN2PDE10ACYP1A2PPARGALDH1A1 | |
| SCHEMBL7101204 | 0.77 | HSD17B10 (0.47) | SMN1; SMN2POLBCRBNHSD17B10PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |