Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7098437 | 0.84 | HSD17B10 (0.41) | HSD17B10SIRT2SIRT1PTGER4CRBN | |
| SCHEMBL27599860 | 0.81 | PDE10A (0.39) | HSD17B10PPARGSIRT2SIRT1PTGER4 | |
| SCHEMBL3950784 | 0.80 | TP53 (0.50) | HSD17B10PPARGSIRT2SIRT1PTGER4 | |
| SCHEMBL5317401 | 0.79 | HSD17B10 (0.73) | HSD17B10SIRT2SIRT1PTGER4CRBN | |
| SCHEMBL27600144 | 0.79 | MAPK1 (0.46) | TP53MAPTHPGDHTTMEN1 | |
| SCHEMBL1625963 | 0.79 | TP53 (0.54) | HSD17B10PPARGSIRT2SIRT1PTGER4 | |
| SCHEMBL28754629 | 0.78 | PDE10A (0.40) | HSD17B10PPARGPTGER4CRBNTP53 | |
| SCHEMBL27600130 | 0.78 | PDE10A (0.40) | MAPTHPGDALDH1A1RAB9A | |
| SCHEMBL27600071 | 0.78 | PDE10A (0.40) | HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL27599854 | 0.78 | ALDH1A1 (0.51) | CRBNMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |