Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | GAPDH | P04406 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476254 | 0.90 | KDM4E (0.50) | MTNR1AMTNR1BALDH1A1GAPDHMAPT | |
| SCHEMBL8513832 | 0.88 | MTNR1A (0.55) | MTNR1AMTNR1BBACE1 | |
| SCHEMBL8525039 | 0.86 | MTNR1A (0.54) | MTNR1AMTNR1BALDH1A1HPGDCYP2D6 | |
| SCHEMBL27961287 | 0.84 | CYP2D6 (0.51) | MTNR1AMTNR1BCYP2D6L3MBTL1TDP1 | |
| SCHEMBL13612582 | 0.82 | ESR1 (0.56) | CYP2D6NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL13133137 | 0.82 | PDGFRB (0.47) | MTNR1AMTNR1BALDH1A1HPGDGLA | |
| SCHEMBL443271 | 0.81 | CYP1A2 (0.57) | MTNR1AMTNR1BALDH1A1HPGDCYP2D6 | |
| SCHEMBL29869216 | 0.81 | CYP1A2 (0.57) | MTNR1AMTNR1BALDH1A1HPGDCYP2D6 | |
| SCHEMBL2169155 | 0.81 | BACE1 (0.50) | MTNR1AMTNR1BBACE1ALDH1A1HPGD | |
| SCHEMBL26036680 | 0.81 | MAOB (0.50) | ALDH1A1HPGDCYP1A2NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1125044-C | Novel prostaglandin synthase inhibitors | DU PONT MERCK PHARMA (US) | 2003-10-22 | — | — | CN | disclosed |
| EP-0952227-B1 | A bio-resolution process | COUNCIL SCIENT IND RES (IN) | 2003-09-03 | — | — | EP | disclosed |
| EP-0952227-A1 | A bio-resolution process | Council of Scientific and Industrial Research (IN) | 1999-10-27 | — | — | EP | disclosed |
| US-5695774-A | Use of nabumetone or 6-methoxynaphthyl acetic acid for the treatment of dementia | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | disclosed |
| US-5695774-A | Use of nabumetone or 6-methoxynaphthyl acetic acid for the treatment of dementia | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | disclosed |
| CN-1166167-A | Novel prostaglandin synthase inhibitors | DU PONT MERCK PHARMA (US) | 1997-11-26 | — | — | CN | disclosed |
| EP-0708641-A1 | USE OF NABUMETONE OR 6-METHOXYNAPHTHYL ACETIC ACID FOR THE TREATMENT OF DEMENTIA | SMITHKLINE BEECHAM PLC (GB) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002399-A1 | USE OF NABUMETONE OR 6-METHOXYNAPHTHYL ACETIC ACID FOR THE TREATMENT OF DEMENTIA | SMITHKLINE BEECHAM PLC (GB) | 1995-01-26 | — | — | WO | disclosed |