Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 9/20 | 0.67 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.67 |
| ▸ | ABCC8 | Q09428 | 8/20 | 0.67 |
| ▸ | KCNJ8 | Q15842 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097711 | 0.83 | ABCC9 (0.82) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL15450534 | 0.81 | GPR174 (0.81) | SMN1; SMN2GPR174HPGDALDH1A1HSD17B10 | |
| SCHEMBL7101209 | 0.80 | ABCC9 (0.77) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7095119 | 0.80 | ABCC9 (0.77) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL4255051 | 0.80 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7855566 | 0.80 | ABCC9 (0.77) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL4255048 | 0.80 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7855041 | 0.80 | ABCC9 (1.00) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7853122 | 0.80 | ABCC9 (0.77) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7099014 | 0.80 | ABCC9 (0.66) | ABCC9KCNJ11ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | claimed |
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |