Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29874430 | 0.73 | HTR2A (0.44) | NOTUMHTR2AHTR2C | |
| SCHEMBL3050639 | 0.73 | HTR2A (0.44) | NOTUMHTR2AHTR2C | |
| SCHEMBL1873666 | 0.67 | NOTUM (0.42) | NOTUMHTR2AHTR2CDAOSIGMAR1 | |
| Benzoquinone SCHEMBL6697569 | 0.67 | NOTUM (0.42) | NOTUMHTR2AHTR2CDAOHTR1A | |
| SCHEMBL6712342 | 0.66 | HTR2A (0.58) | NOTUMHTR2AHTR2CSIGMAR1ALDH1A1 | |
| SCHEMBL34463390 | 0.65 | NOTUM (0.56) | NOTUMHTR2AHTR2CMAPTDAO | |
| SCHEMBL15466517 | 0.65 | NOTUM (0.43) | NOTUMHTR2AHTR2CDAO | |
| SCHEMBL7396809 | 0.65 | NOTUM (0.56) | NOTUMHTR2AHTR2CMAPTDAO | |
| SCHEMBL4829868 | 0.64 | KMT2A (0.37) | MAPTALDH1A1 | |
| SCHEMBL10917532 | 0.64 | HTR2A (0.39) | NOTUMHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328525-A2 | 2,3,4,5-TETRAHYDRO-1H-[1,4]DIAZEPINO[1,7-A]INDOLE COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2001072752-A2 | 2,3,4,5-TETRAHYDRO-1H-[1,4]DIAZEPINO[1,7-a]INDOLE COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-04 | — | — | WO | disclosed |