Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.34 |
| ▸ | HTR2C | P28335 | 5/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1873666 | 0.90 | NOTUM (0.42) | NOTUMHTR2AHTR2CDAO | |
| Hydroxyamine SCHEMBL9656514 | 0.85 | NOTUM (0.39) | NOTUMHTR2AHTR2CDAO | |
| SCHEMBL4500824 | 0.76 | HTR2A (0.34) | NOTUMHTR2AHTR2C | |
| SCHEMBL15466517 | 0.73 | NOTUM (0.43) | NOTUMHTR2AHTR2CDAO | |
| SCHEMBL10960778 | 0.69 | NOTUM (0.37) | NOTUMHTR2AHTR2C | |
| SCHEMBL7100239 | 0.67 | NOTUM (0.45) | NOTUMHTR2AHTR2CDAOHTR1A | |
| Water SCHEMBL30136134 | 0.66 | — | — | |
| SCHEMBL732858 | 0.65 | KMT2A (0.37) | HTR2AHTR2C | |
| SCHEMBL3050639 | 0.65 | HTR2A (0.44) | NOTUMHTR2AHTR2C | |
| SCHEMBL10917532 | 0.65 | HTR2A (0.39) | NOTUMHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006054-A1 | Cytotoxic N-unsubstituted indoles and cyclopent(b)indoles and method of making and using same | NATIONAL INSTITUTES OF HEALTH | 2004-01-08 | — | — | US | disclosed |
| WO-2001043741-A1 | CYTOTOXIC N-UNSUBSTITUTED INDOLES AND CYCLOPENT(B)INDOLES AND METHOD OF MAKING AND USING SAME | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006054-A1 | Cytotoxic N-unsubstituted indoles and cyclopent(b)indoles and method of making and using same | TDO2, MDH2, CYP11B1 | NOTUM 1132/4885HTR2A 2309/4885HTR2C 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.