Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.42 |
| ▸ | ITGAV | P06756 | 3/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | TACR2 | P21452 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102257 | 0.91 | KMT2A (0.42) | LMNAITGB3ITGA2BITGAVCTSA | |
| SCHEMBL7099318 | 0.82 | ITGB3 (0.42) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL7100316 | 0.80 | ITGB3 (0.39) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL7261894 | 0.77 | S1PR3 (0.46) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL7099303 | 0.74 | KDM4E (0.43) | LMNAITGB3ITGA2BITGAVITGB5 | |
| SCHEMBL11400562 | 0.74 | ITGB3 (0.58) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL7099324 | 0.73 | ITGB3 (0.41) | LMNAITGB3ITGA2BITGAVALDH1A1 | |
| SCHEMBL7099306 | 0.71 | ITGB3 (0.51) | ITGB3ITGA2BITGAVALDH1A1 | |
| SCHEMBL7102252 | 0.71 | ITGB3 (0.39) | LMNAITGB3ITGA2BITGAVCTSA | |
| SCHEMBL17234581 | 0.71 | ITGB3 (0.38) | LMNAPOLBITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649613-B1 | Integrin inhibitors | MERCK PATENT GMBH (DE) | 2003-11-18 | — | — | US | disclosed |
| EP-1194401-B1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-09-10 | — | — | EP | disclosed |
| EP-1194401-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001005753-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-25 | — | — | WO | disclosed |