Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099008 | 0.89 | SMN1; SMN2 (0.40) | HTTSMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL7098251 | 0.85 | SMN1; SMN2 (0.39) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7102170 | 0.83 | SMN1; SMN2 (0.36) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7097040 | 0.82 | ESR1 (0.40) | HTTSMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL7100074 | 0.82 | NPC1 (0.42) | SMN1; SMN2PGK1ALDH1A1MAPTPOLB | |
| SCHEMBL6426223 | 0.82 | PSEN1 (0.45) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27600113 | 0.82 | PSEN1 (0.47) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27599858 | 0.81 | CYP1A2 (0.40) | MAT2APGK1ALDH1A1MAPTHPGD | |
| SCHEMBL7105813 | 0.80 | ALDH1A1 (0.43) | HTTSMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL1625820 | 0.79 | AR (0.37) | HTTHSD17B10CYP11B2MAT2APGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |