Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070118 | 0.90 | KDM4E (0.43) | L3MBTL1RAB9ANPC1METAP2SMN1; SMN2 | |
| SCHEMBL4063845 | 0.82 | L3MBTL1 (0.44) | L3MBTL1RAB9ANPC1METAP2PAX8 | |
| SCHEMBL4058774 | 0.80 | KDM4E (0.42) | L3MBTL1RAB9ANPC1PAX8SMN1; SMN2 | |
| SCHEMBL4058765 | 0.72 | CALCA (0.48) | L3MBTL1RAB9ANPC1METAP2SMN1; SMN2 | |
| SCHEMBL7258267 | 0.69 | KDM4E (0.53) | L3MBTL1RAB9ANPC1PAX8SMN1; SMN2 | |
| SCHEMBL30406784 | 0.67 | MAPT (0.51) | L3MBTL1RAB9ANPC1METAP2PAX8 | |
| SCHEMBL26908045 | 0.67 | MAPT (0.51) | L3MBTL1RAB9ANPC1METAP2PAX8 | |
| SCHEMBL6646416 | 0.66 | KDM4E (0.49) | L3MBTL1RAB9AMETAP2PAX8SMN1; SMN2 | |
| SCHEMBL4071983 | 0.66 | KDM4E (0.56) | L3MBTL1RAB9APAX8SMN1; SMN2KDM4E | |
| SCHEMBL2479793 | 0.65 | MAPT (0.53) | L3MBTL1RAB9ANPC1METAP2PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030930-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2002-04-18 | — | — | WO | disclosed |