Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL852449 | 0.97 | CA4 (0.90) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5557290 | 0.95 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL6657504 | 0.95 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL9780898 | 0.95 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29103874 | 0.95 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5034928 | 0.95 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL7105323 | 0.95 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL31415098 | 0.93 | CA4 (0.81) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5617378 | 0.92 | CA4 (0.90) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5617376 | 0.92 | CA4 (0.90) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124124-B2 | Compressed tablet containing non-steroid antiinflammatory drug | RECKITT BENCKISER HEALTHCARE (UK) LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| EP-1392249-B1 | NSAID FORMULATION COMPRISING A GRANULAR COMPOSITION AND AN EXTRA-GRANULAR COMPOSITION | RECKITT BENCKISER HEALTHCARE (GB) | 2009-12-02 | — | — | EP | disclosed |
| EP-1235558-B1 | COMPRESSED TABLET COMPOSITION COMPRISING A NSAID | BOOTS CO PLC (GB) | 2006-05-03 | — | — | EP | disclosed |
| US-20050106235-A1 | Nsaid formulation comprising a granular composition and an extra-granular composition | RECKITT BENCKISER HEALTHCARE (UK) LIMITED (GB) | 2005-05-19 | — | — | US | disclosed |
| EP-1392249-A1 | NSAID FORMULATION COMPRISING A GRANULAR COMPOSITION AND AN EXTRA-GRANULAR COMPOSITION | The Boots Company PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| US-20030203026-A1 | Therapeutic agents | RECKITT BENCKISER HEALTHCARE (UK) LIMITED (GB) | 2003-10-30 | — | — | US | disclosed |
| WO-2002098392-A1 | NSAID FORMULATION COMPRISING A GRANULAR COMPOSITION AND AN EXTRA-GRANULAR COMPOSITION | THE BOOTS COMPANY PLC (GB) | 2002-12-12 | — | — | WO | disclosed |
| EP-1235558-A2 | COMPRESSED TABLET COMPOSITION COMPRISING A NSAID | The Boots Company PLC (GB) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001041733-A2 | COMPRESSED TABLET COMPOSITION COMPRISING A NSAID | THE BOOTS COMPANY PLC (GB) | 2001-06-14 | — | — | WO | disclosed |