Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6657504 | 0.97 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL710052 | 0.97 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5557290 | 0.97 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL9780898 | 0.97 | CA4 (0.85) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29103874 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL31415098 | 0.95 | CA4 (0.81) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29802314 | 0.95 | CA4 (0.90) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL28131934 | 0.95 | CA4 (0.80) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL8065018 | 0.95 | CA4 (0.90) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL3657 | 0.95 | CA4 (1.00) | CA4ALDH1A1CASP1FFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12012495-B1 | 3-D printable expendable lost foam pattern | BRUNSWICK CORPORATION (US) | 2024-06-18 | — | — | US | claimed |
| CN-103351561-A | Polyvinyl alcohol/montmorillonite nano-alloy foam material and preparation method thereof | UNIV BEIJING TECH & BUSINESS | 2013-10-16 | — | — | CN | claimed |
| JP-2001519835-A | — | — | 2001-10-23 | — | — | JP | claimed |
| EP-0846035-A4 | MICROCELLULAR FOAM PLANK | ASTRO VALCOUR INC (US) | 1998-12-09 | — | — | EP | claimed |
| EP-0846035-A1 | MICROCELLULAR FOAM PLANK | ASTRO-VALCOUR, INCORPORATED (US) | 1998-06-10 | — | — | EP | claimed |
| WO-1997007907-A1 | MICROCELLULAR FOAM PLANK | ASTRO-VALCOUR, INC. (US) | 1997-03-06 | — | — | WO | claimed |
| US-12012495-B1 | 3-D printable expendable lost foam pattern | BRUNSWICK CORPORATION (US) | 2024-06-18 | — | — | US | disclosed |
| US-11794530-B2 | Tire with intrinsic sealant containing intrinsic cellular innermost layer | Triangle Tyre Co. Ltd. (CN) | 2023-10-24 | — | — | US | disclosed |
| CN-116917146-A | Tyre with internal porous noise damping part | 三角轮胎股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116847999-A | Tyre with an inner porous innermost layer containing an inner sealant | 三角轮胎股份有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-112368322-B | Modified polypropylene resin and method for producing same, and extruded foam pellets using same and method for producing same | 株式会社钟化 | 2023-09-15 | — | — | CN | disclosed |
| US-11642430-B2 | Solid air freshener | ECOLAB USA INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20220258546-A1 | Tires with Intrinsic Cellular Noise Damper | Triangle Tyre Co. Ltd. (CN) | 2022-08-18 | — | — | US | disclosed |
| EP-0627984-A1 | A FLEXIBLE POLYMERIC FOAM FOR USE AS AN INSULATOR AND A MOISTURE RETARDANT AND A PROCESS FOR PRODUCING IT | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-12-14 | — | — | EP | disclosed |
| WO-1994026258-A1 | ORAL COMPOSITIONS CONTAINING TRICLOSAN FOR THE TREATMENT OF APHTHOUS ULCERS | UNILEVER N.V. (NL) | 1994-11-24 | — | — | WO | disclosed |
| EP-0608143-A1 | A thermoplastic foam having improved cushioning and long term durability | GENERAL ELECTRIC COMPANY (US) | 1994-07-27 | — | — | EP | disclosed |
| WO-1993014923-A1 | A FLEXIBLE POLYMERIC FOAM FOR USE AS AN INSULATOR AND A MOISTURE RETARDANT AND A PROCESS FOR PRODUCING IT | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-08-05 | — | — | WO | disclosed |
| EP-0260843-A1 | Chemical blowing agent compositions and use thereof in making moulded foamed articles | QUANTUM CHEMICAL CORPORATION (a Virginia corp.) (US) | 1988-03-23 | — | — | EP | disclosed |
| US-4127645-A | CANDY, LEAVENING AGENT AND AN ACIDULANT | LIFE SAVERS, INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4056587-A | Process for expanding | W. R. GRACE & CO. (US) | 1977-11-01 | — | — | US | disclosed |