Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973866 | 0.78 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CSLC2A1HSPB1 | |
| Ammonia Solution, Strong SCHEMBL7429890 | 0.77 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CSLC2A1MAPT | |
| SCHEMBL1581001 | 0.75 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CSLC2A1HSPB1 | |
| Formamide SCHEMBL28333185 | 0.74 | SLC2A1 (0.46) | ADRA2AADRA2BADRA2CSLC2A1MAPT | |
| Hydrochloric Acid SCHEMBL7848303 | 0.74 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CSLC2A1HSPB1 | |
| SCHEMBL11815139 | 0.74 | HSPB1 (0.45) | ADRA2AADRA2BADRA2CSLC2A1HSPB1 | |
| SCHEMBL21962089 | 0.74 | KMT2A (0.45) | ADRA2AADRA2BADRA2CSLC2A1HSPB1 | |
| SCHEMBL397421 | 0.74 | MAPT (0.49) | ADRA2AADRA2BADRA2CSLC2A1HSPB1 | |
| SCHEMBL27575647 | 0.73 | KMT2A (0.48) | ADRA2AADRA2BADRA2CMAPTLMNA | |
| SCHEMBL19089741 | 0.71 | CYP1A2 (0.49) | ADRA2AADRA2BADRA2CSLC2A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |