Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256349 | 0.76 | KDM4E (0.36) | KDM4EPSMD14ALDH1A1MAPTHPGD | |
| SCHEMBL6257907 | 0.76 | KDM4E (0.42) | KDM4EPSMD14ALDH1A1MAPTHPGD | |
| SCHEMBL6724777 | 0.74 | TSHR (0.40) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL6261894 | 0.74 | KDM4E (0.41) | KDM4EPSMD14ALDH1A1MAPTHPGD | |
| SCHEMBL6254208 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL6255590 | 0.72 | KDM4E (0.41) | KDM4EPSMD14ALDH1A1MAPTHPGD | |
| SCHEMBL6730039 | 0.71 | MEN1 (0.40) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL6259014 | 0.69 | HSD17B10 (0.38) | KDM4EPSMD14ALDH1A1MAPTHPGD | |
| SCHEMBL15134641 | 0.65 | PARP10 (0.43) | HPGDMEN1KMT2APARP15PARP10 | |
| SCHEMBL11396217 | 0.64 | MEN1 (0.43) | MAPTHPGDMEN1KMT2APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |